Course Description
Despite decades of research, the neurobiological basis of schizophrenia remains elusive. Extrapolating connections between disparate levels of analysis may provide a more comprehensive understanding of at least some aspects of this complex disorder. Electroencephalography (EEG) is one way to measure aspects of brain functioning that could be helpful when learning about different psychiatric disorders. The auditory steady state response (ASSR) is an EEG measure of neural synchrony and oscillation that has been extensively studied in this population and may represent a potential biomarker of schizophrenia. Moreover, the ASSR can be recorded in rodent and non-human primate models. At the cellular level, the ASSR is thought to rely on the interaction between excitatory glutamatergic and inhibitory GABA systems via the NMDA receptor, which may be disrupted in individuals with schizophrenia. Coordinated neural firing, as measured by EEG, is also likely impacted by higher levels of neuroinflammation found in different stages of the disorder. On a behavioral level, neural oscillations within the gamma (40 Hz) frequency range have been associated with sensory and cognitive functioning, both of which are also disrupted in individuals with schizophrenia. Intriguing rodent studies have shown that gamma range stimulation may have lasting neurophysiological impacts. Therefore, the ASSR is a cross-species paradigm that allows us to probe basic neural network alterations that may be responsible for some of the cognitive and perceptual symptoms found in those with schizophrenia.
Speaker
In-Person Location
Centennial Complex, Room 3208
*Online attendance option available